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Year : 2021  |  Volume : 10  |  Issue : 2  |  Page : 108-112

Antimicrobial use in a neonatal intensive care unit during a 4-year period

1 Department of Pediatrics and Child Care, Pediatric Infectious Diseases Unit, Santa Casa de São Paulo School of Medicine, São Paulo, SP, Brazil
2 Caxias do Sul Federal University, Caxias do Sul, RS, Brazil

Correspondence Address:
Eitan Naaman Berezin
Department of Pediatrics and Child Care, Pediatric Infectious Diseases Unit, Santa Casa de São Paulo School of Medicine, Av Roberto Lorenz 482 CEP 05611-050 São Paulo, SP
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jcn.jcn_143_20

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Background: Due to the difficulty in the diagnosis, high morbidity, and mortality, many empirical antimicrobial treatments have been used on suspicion of neonatal sepsis, leading to inappropriate use of broad-spectrum antibiotics and prolonged duration of therapies. Aim: The aim of this study was to characterize the antimicrobial use in the neonatal intensive care unit (NICU) in 4 years. Methods: This was a retrospective study from January 2013 to December 2016, in a 6-bed NICU from a private small hospital from the South of Brazil. To evaluate the antibiotic use, all results were quantified using days of therapy (DOT) measurement per 100 patients-day (DOT/100PD). Results: Three hundred and sixty-six patients were admitted into the unit. Total antimicrobial use decreased from 78.7 DOT/100PD in 2013 to 73.3 DOT/100PD in 2016. Individually, we observed a reduction from 22.2 to 15.9 DOT/100PD in ampicillin use and 22.7 to 14.2 DOT/100PD for gentamicin. Vancomycin utilization was stable 12.9 DOT/100PD, while oxacillin utilization is increased from 0.6 DOT/100PD to 7.8 DOT/100PD. Conclusions: The changes in antibiotic use during the years could be the result of the multiprofessional efforts in practicing antibiotic stewardship.

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