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Year : 2021  |  Volume : 10  |  Issue : 2  |  Page : 145

Reply to the letter to the editor

Division of Pediatric Cardiology, Department of Pediatrics, J.N Medical College AMU, Aligarh, Uttar Pradesh, India

Date of Submission03-Apr-2021
Date of Acceptance21-Apr-2021
Date of Web Publication15-May-2021

Correspondence Address:
Shaad Abqari
Assistant Professor, Division of Pediatric Cardiology, Department of Pediatrics, J.N Medical College AMU, Aligarh - 202 002, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2249-4847.316182

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How to cite this article:
Abqari S. Reply to the letter to the editor. J Clin Neonatol 2021;10:145

How to cite this URL:
Abqari S. Reply to the letter to the editor. J Clin Neonatol [serial online] 2021 [cited 2023 Mar 21];10:145. Available from: https://www.jcnonweb.com/text.asp?2021/10/2/145/316182

Thanks for your queries

We thank the reader who took keen interest in our article.

The attempt in this study is to look for the prevalence of pulmonary arterial hypertension (PAH) among high-risk neonates. As far as definition of persistent pulmonary hypertension of the newborn (PPHN) is considered, it is the standard definition of PAH with desaturation and hypoxemia. As is clearly mentioned in the methodology, it is the “PAH” as the pulmonary artery systolic pressure of >50% of systolic blood pressure (SBP). If along with PAH there is reversal of shunt, then only we have labeled it is PPHN, which explains its prevalence as per other studies. Hemodynamic instability and outcome - As mentioned by the reviewer, as there will be hemodynamic instability and fall of SBP or rise in pulmonary artery pressure so that PAP rises above the SBP and there is reversal of shunt, the child will be labeled as in the stage of PPHN as happens in most of the cases of perinatal asphyxia. Confounding factors - The study's aim is to look at the prevalence of PAH and its effect on the outcome of the neonates. The role of inotropes/pulmonary vasodilators/ventilation/fluid management or even use of ECMO and how it is influences the outcome is not part of the study. Each neonate received the standard neonatal care pertaining to PAH/PPHN as per the neonatal intensive care unit protocols.

I hope that we have cleared some of the doubts. Please feel free to ask any other queries; we will be delighted to answer that and your inputs will enable us to improve further in our research on this topic in the future.

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Conflicts of interest

There are no conflicts of interest.


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